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Benzyl alcohol toxicity in neonates was documented in published case series and FDA communications beginning in the early 1980s, describing a syndrome characterised by metabolic acidosis, gasping respirations, CNS depression, and in some cases death — now referred to as 'gasping syndrome.' Neonates lack the hepatic enzyme capacity to metabolise benzyl alcohol effectively, leading to toxic accumulation of benzoic acid

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Additionally, nanocarriers can be used to improve the stability and delivery of peptide drugs when sonication is applied