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Graphical Abstract Keywords Hyperuricemia, Microbiota, Physical activity, Caveolae, Uric acid metabolism, Cardiovascular diseases, Metabolic syndrome Introduction Hyperuricemia (HU), a metabolic disorder characterized by elevated levels of uric acid (UA) in the bloodstream, is a significant global health concern

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DHA (5–50 μg/ml) protected neurons against cytotoxicity, inhibited both nitrogen oxide (NO) production and Ca 2+ influx, and increased the activities of antioxidant enzymes of glutathione peroxidase and glutathione reductase (Wang et al., 2003) in cell cultures

while reducing oxidative stress that triggers discolouration