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Frontiers | Metabolic mediators: microbial-derived metabolites as key regulators of anti-tumor immunity, immunotherapy, and chemotherapy

Central administration demonstrated early feasibility: intracerebroventricular (icv) or intrathecal delivery robustly increased wakefulness and locomotion in rodents [49,50], but invasiveness, instability, and potential desensitization restrict clinical translation [51,52]

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